Today, Ilya’s screen on intestinal organoid formation was published in Nature. He treated 400,000 organoids with an annotated library of 3000 compounds to infer a map of functional interactions. He also identified a small compound inhibiting RXR that maintains the regenerative state both in intestinal organoids and in mice. Check out this beautiful paper that also made it on the Nature cover. If you want to learn more about the journey that led to this publication, check out Ilya’s Behind the paper.
Paper on phenotypic landscape of intestinal organoids published